Diabetes News

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Deletion of Protein Kinase D1 in Pancreatic Beta Cells Impairs Insulin Secretion in High-Fat Fed Mice

Beta-cell adaptation to insulin resistance is necessary to maintain glucose homeostasis in obesity. Failure of this mechanism is a hallmark of type 2 diabetes (T2D). Hence, factors controlling functional beta-cell compensation are potentially important targets for the treatment of T2D. Protein ki...

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Negative Regulation of TRPA1 by AMP-activated Protein Kinase in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy

AMP activated protein kinase (AMPK) is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. Here, we dis...

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Insights from Molecular Characterization of Adult Patients of Families with Multigenerational Diabetes Mellitus.

Multigenerational diabetes of the adulthood is a mostly overlooked entity, simplistically comprised in the large basin of type 2 diabetes. The general aim we are pursuing in last years is to unravel the genetic causes of such form of diabetes. Identifying among families with multigenerational dia...

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Objectively Measured Physical Activity, Sedentary Behavior and Genetic Predisposition to Obesity in US Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Studies using self-reported data suggest gene-physical activity interaction on obesity, yet the influence of sedentary behavior, distinct from lack of physical activity, on genetic associations with obesity remains unclear. We analyzed interactions of accelerometer-measured moderate-to-vigorous p...

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Inhibition of Cdk5 Promotes {beta}-cell Differentiation from Ductal Progenitors

Inhibition of notch signalling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of ~2200 small molecules in zebrafish we identified an inhibitor of Cdk5 (roscovitine), which potentiated formation of β-cells along...

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